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S100A12 homodimer (human) ELISA kit

S100A12 belongs to the S100 family, called calgranulin. Calgranulins are endogenous molecules released in response to environmental triggers and cellular damage. Also known as damage-Associated Molecular Pattern Molecules (DAMPs), these proteins play an important role in a diverse range of physiological and pathological processes, such as host defense, wound healing, autoimmunity, oncogenesis and inflammation, among others.

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(010-8832-6303)

제품소개

Territorial Availability: Available worldwide directly through Bertin or your local distributor

Technical Warning: Check the Additional Items Required section of this kit booklet to verify if UltraPure Water (Milli-Q or equivalent) is needed for this assay

Synonyms:

calgranulin C

EN-RAGE

MRP6

Correlated keywords:

innate immunity

inflammation

trauma

infection

heat

stress

DAMP

calgranulin

Product Overview:
Enzyme ImmunoAssay (EIA) is a technique to detect and quantify antigens (proteins, hormones…) or antibodies in samples. It relies on the ability of an antibody to bind a specific antigen. Either the antibody or the antigen is labelled with an enzyme whose substrate is a chromogen or a fluorogen converted in a measurable product (color or fluorescence).|Enzyme-linked Immunosorbent Assay (ELISA) is a type of EIA using a solid phase (ex: microtiter plate) coated with an antigen immobilizing the molecule to detect. Over the time, scientists have extended the term ELISA to EIAs using an antibody coating the solid phase. That explains why our EIA kits using coated antibodies are also called ELISA kits.|Bertin Bioreagent’s expertise is to develop analytical tools for biomarkers. S100A12 belongs to the S100 family, called calgranulin. Calgranulins are endogenous molecules released in response to environmental triggers and cellular damage. Also known as Damage-Associated Molecular Pattern Molecules (DAMPs), these proteins play an important role in a diverse range of physiological and pathological processes, such as host defense, wound healing, autoimmunity, oncogenesis and inflammation, among others . | This assay is a sanwich based ELISA kit allowing accurate quantification of S100A12 homodimer in human samples.

Size	96 wells
Shipping	wet ice
Application Media	human serum samples\|dilution at least at 1:5 in 1x Biotin-free ELISA Buffer
Sample volume	Refer to user manual
Standard Curve Range	3.1 - 400.0 ng/mL
Custom Code	3822000000
UNSPSC code	41116104

Dubois C, Payen D, Simon S, Junot C, Fenaille F, Morel N, and Becher F. (2020). Top-Down and Bottom-Up Proteomics of Circulating S100A8/S100A9 in Plasma of Septic Shock Patients. Journal of Proteome Research 19 (2), 914-925 https://doi.org/10.1021/acs.jproteome.9b00690 Dubois C, Marcé D, Faivre V, Lukaszewicz AC, Junot C, Fenaille F, Simon S, Becher F, Morel N, Payen D. (2019). High plasma level of S100A8/S100A9 and S100A12 at admission indicates a higher risk of death in septic shock patients. Sci Rep. 30;9(1):15660. https://doi.org/10.1038/s41598-019-52184-8 PMID: 31666644; PMCID: PMC6821805 Garcia AF, Lopes JLS, Costa-Filho AJ, Wallace BA, Araujo APU (2013) Membrane Interactions of S100A12 (Calgranulin C). PLoS ONE 8(12): e82555

Holzinger, D., Foell, D., & Kessel, C. (2018). The role of S100 proteins in the pathogenesis and monitoring of autoinflammatory diseases. Molecular and cellular pediatrics, 5(1), 7

Kerkhoff C., Radon Y., Flaßkamp H. (2014) Alarmins. In: Parnham M. (eds) Encyclopedia of Inflammatory Diseases. Birkhäuser, Basel.

Oesterle A, Bowman MA (2015) S100A12 and the S100/Calgranulins: Emerging Biomarkers for Atherosclerosis and Possibly Therapeutic Targets. Arterioscler Thromb Vasc Biol. 35(12):2496-2507

Wang, X., Sun, Z., Tian, W. et al. (2020) S100A12 is a promising biomarker in papillary thyroid cancer. Sci Rep 10, 1724

주문정보

CAT.No	품명	규격	비고
A05084	S100A12 homodimer (human) ELISA kit	96 wells